Endocrine Abstracts

Introduction: Primary aldosteronism (PA) is characterized by symptoms caused by hypertension and hypokalemia. Some cardiovascular events are found to be more common due to the additional negative effect of aldosterone. The aim of the study was to analyse clinical characteristics of the PA due to adenoma (APA) and to compare the frequency of cardiovascular diseases with those found in adrenal Cushing’ syndrome (CS) and adrenal adenoma associated with essential hypertension...

Background: Individuals with gender incongruence receive gender affirming therapy which is fundamental to sex reassignment. Cross sex hormone treatment both improves and impairs several surrogate markers of cardiovascular risk. In the aging population of transsexual persons, we are called to address clinical endpoints of the long-term gender affirming hormone therapy.Aim: Aim was to assess changes in the fasting serum lipid profile during gender affirmin...

Calcitonin is a polypeptide hormone synthesized and secreted by the parafollicular cells of the thyroid gland, and has been considered as a good marker for medullary thyroid carcinoma. But several physiologic and pathologic conditions other than medullary thyroid carcinoma have been associated with increased levels of calcitonin. A 39-year old woman was admitted to our hospital for further testing due to high calcitonin level (467 ng/L) measured by immunochemiluminometric assa...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...

Introduction: Neurogenic hypertension is associated with unilateral neurovascular compression of the brainstem and cranial nerves V, IX-X, VII, VIII. Causes may include nerve injury, vascular compression, tumors. Symptomatology seems hyperactive dysfunction syndrome of the cranial nerves. In the clinical picture, it can be seen trigeminal neuralgia, vertigo, tinnitus, hemifacial spasm, and in some cases hypertension.Case report: Female patient, 45 years ...

Introduction: Changes in thyroid function have significant impact on the cardiovascular system.Methods: In a group of 37 subjects the level of thyroid hormones FT4, FT3, and TSH were measured. Then carried out short-term analysis for 30 min measureing variability of blood pressure with non-invasive TASK FORCE monitor. Registered data were analyzed by spectral analysis of variability. Statistical analysis were done by Pearson correla...

AI are incidentally discovered adrenal masses without any prior suspicions of adrenal disease. They are most frequently hormonally inactive, with arterial hypertension (AH) as a common finding.The aim was to determine upright and supine PR and ALD levels in patients with AI, normotensive and hypertensive.Two hundred and eight patients (148 women and 60 men, mean age 55.08±11.02 years, mean BMI 27.91±4.6 kg/m2) ...

Considering that adrenal tumors are frequent in patients with congenital adrenal hyperplasia (82% in homozygote and 45% in heterozygote), Synacten test was at first introduced as marker of congenital adrenal deficiency in patient with adrenal incidentaloma. Recent studies showed normal and exaggerated cortisol response in more than 50% of patient with nonhypersecretory adrenal incidentaloma and more than 70% of patients with adrenal incidentaloma and subclinical hypercorticism...

Many studies have shown insulin resistance (IR) in majority of patients with adrenal incidentaloma. The euglycaemic hyperinsulinaemic glucose clamp technique is still considered as ‘golden standard’ for evaluation of insuline sensitivity. These methods are also complicated, labor-intensive procedure better for small research studies. Today, several surrogate indexes for insulin sensitivity were introduced such as: HOMA, QUIQI or G/IR. Some studies showed that QUIQI h...

Subclinical hyperthyroidism is a biochemical diagnosis defined with suppressed levels of TSH and normal levels of thyroid hormones. One of the main metabolic responses to thyroid hyperfunction is peripheral lipolysis and release of free fatty acids (FFA). The aim of this study was to compare levels of cholesterol, LDL, HDL and triglycerides in persons with subclinical hyperthyroidism to age and BMI matched euthyroid healthy control. We evaluated 45 persons in two groups: 1st g...